Trade, migration and cross-border human mobility are inherently interconnected; without people, goods and services would be unable to cross borders and contribute to formal economic development. Cross-border traders, due to their frequent crossing of international borders, are mobile populations and therefore of interest to IOM. This think piece examines the interrelationship between cross-border trade and human mobility across borders. It argues that the link between migration, human mobility and trade is neglected. This think piece on case studies looks at examples and practices from four COMESA Member States – the Democratic Republic of the Congo, Malawi, Zambia and Zimbabwe. It is the intention of this piece to contribute to policy and operational responses that integrate human mobility and border management into trade facilitation responses from an immigration and border management perspective.