Mexico receives significant flows of migrants in transit, mostly directed to the USA, and of temporary and cross border migrants workers. This study explores their exposure and vulnerability to violence and human right violations, as well as to disasters triggered by natural hazards. Its purpose is to identify the main areas of transit and destination of the migration flows, and the risks migrants face in these areas; the country’s migration trends and potential future scenarios; and the migrants’ specific conditions of vulnerability, in accordance to their migration status and individual characteristics. The study also looks at existing institutional structures for emergency preparedness and response in the country and how they include migrants and non-nationals in general. Given the complexity of Mexico’s migration system, the study focuses specifically on the Soconusco region, located on the Guatemalan border, one of the main destination of temporary migrant workers in the country.